---
title: "5-Amino-1MQ: what sources report"
url: https://humanpeptides.fyi/peptides/5-amino-1mq
site: humanpeptides.fyi
last_reviewed: 2026-10-11
---
# 5-Amino-1MQ
> humanpeptides.fyi makes no claims of its own. Every statement below reports what a cited source says, with its link. Not medical advice.
5-Amino-1MQ: Small-molecule (not a peptide) membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme in fat tissue that consumes NAD+ precursors. The sources cited here most often discuss it for: Fat loss, mice; Aged muscle regeneration, mice; Metabolic health, mice. Evidence label: Preclinical.
## At a glance
- **Type:** Not a peptide
- **Family:** Weight & Metabolic
- **Evidence label:** Preclinical (2 of 5)
- **Regulatory status:** A March 2026 report on FDA warning letters says FDA inspectors found that compounder GenoGenix made 5-Amino-1MQ, which is ineligible for the section 503B compounding exemptions.
- **Goals discussed:** Fat Loss & Metabolism, Muscle & Tone, Healing & Recovery, Heart, Liver & Kidney
- **Also called:** 5-amino-1-methylquinolinium iodide, 5amino, 5A1MQ, 5AM1
- **Last reviewed:** 2026-10-11
## What is 5-Amino-1MQ?
- Small-molecule (not a peptide) membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme in fat tissue that consumes NAD+ precursors; experimental research compound, no human trials, not FDA-approved. Sources: ,
Not a peptide: a small-molecule inhibitor of the enzyme NNMT, often sold and discussed alongside peptides.
**Regulatory status:** A March 2026 report on FDA warning letters says FDA inspectors found that compounder GenoGenix made 5-Amino-1MQ, which is ineligible for the section 503B compounding exemptions. Source:
## What is 5-Amino-1MQ researched for?
### 1. Fat loss, mice
- Fat loss: in diet-induced obese mice, 11 days of injections cut body weight ~5.1% (controls gained 1.4%), reduced white fat mass ~35% and adipocyte size, and lowered cholesterol ~30% without changing food intake (animal) Sources:
- Goals: [Fat Loss & Metabolism](https://humanpeptides.fyi/objectives/fat-loss)
### 2. Aged muscle regeneration, mice
- Aged muscle regeneration: in 24-month-old mice, activated senescent muscle stem cells, roughly doubled regenerating fiber size and increased peak torque ~70% after injury (animal) Sources: ,
- Goals: [Muscle & Tone](https://humanpeptides.fyi/objectives/muscle), [Healing & Recovery](https://humanpeptides.fyi/objectives/healing)
### 3. Metabolic health, mice
- Obesity-related metabolic dysfunction improved with NNMT inhibition in mice (animal, 2024) Sources:
- Users report modest fat loss, less hunger or alertness; others nothing (anecdotal/Reddit) Sources: ,
- Goals: [Fat Loss & Metabolism](https://humanpeptides.fyi/objectives/fat-loss), [Heart, Liver & Kidney](https://humanpeptides.fyi/objectives/organs)
## What do researchers and users say about 5-Amino-1MQ?
> "Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels."
>
> Neelakantan H, et al., Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice (2018).
Context: Mouse study of methylquinolinium NNMT inhibitors, the compound class sold as 5-Amino-1MQ; no human data.
> "Importantly, improved muSC activity translated not only to larger myofibers after injury but also to greater contractile function, with the peak torque of the TA increased by ~70% in NNMTi-treated mice compared to controls."
>
> Neelakantan H, et al., Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle (2019).
Context: Injured leg muscle in 24-month-old mice; muSC means muscle stem cells and TA is the tibialis anterior muscle.
> "Once this stuff builds up in your system, it really does give you a good clean boost of daily energy without affecting your sleep."
>
> Anonymous user, r/BodyHackGuide, Review: 5-Amino-1MQ Injections.
Context: Self-report from a user also taking the investigational drug retatrutide and other compounds; other commenters in the thread noticed no effect.
## What side effects of 5-Amino-1MQ are reported?
- No observable adverse effects in mouse study; human efficacy, dose and long-term safety unknown Sources: ,
- Mild stomach upset, headaches, fatigue and occasional nausea, mostly when starting. (anecdotal (community guide)) Sources:
- Diarrhea reported with oral tablets by one user also taking retatrutide, so the cause is unclear. (anecdotal) Sources:
- Compounded product quality: FDA cited a facility compounding 5-Amino-1MQ and NAD+ for unsanitary conditions, and three patients given its NAD+ product needed emergency care. (FDA warning letter (reported by BioSpace)) Sources:
## What do peptide guides say about 5-Amino-1MQ?
- **PepEdHub:** PepEdHub describes 5-Amino-1MQ as a small-molecule NNMT inhibitor said to raise NAD+, activate SIRT1 and shrink fat cells, while acknowledging limited long-term human safety data.
- **NCBI PMC:** In obese mice, an NNMT inhibitor cut body weight and white fat and lowered cholesterol without reducing food intake, and the researchers observed no adverse effects.
- **NCBI PMC:** In elderly mice with muscle injury, NNMT inhibition revived muscle stem cells, producing nearly twice the regenerating fiber size and stronger contractions than untreated controls.
- **Seek Peptides:** Seek Peptides notes genotoxicity tests in bacteria, cells and mice were negative, but stresses that human trials are lacking and long-term effects are unstudied even in animals.
## What does the research say, system by system?
### Body & tissues
- White adipose tissue (reduced mass/adipocyte size); skeletal muscle stem cells (animal) Sources: ,
### Hormones & physiology
- Lowered total cholesterol ~30% in obese mice (animal) Sources:
### Cells & mitochondria
- NNMT inhibition preserves NAD+ salvage, supporting muscle stem-cell function and adipocyte metabolism (animal/in vitro) Sources:
### Brain, mood & sleep
- Some users report alertness/focus changes (anecdotal) Sources:
### Weight & metabolism
- ~5% weight loss and 35% less fat mass in obese mice without appetite change (animal) Sources:
### Muscle
- Improved regeneration and strength of aged injured muscle (animal) Sources:
### Also notable
- Commonly taken orally per community guides, at amounts extrapolated from animal work and not validated in humans (amounts omitted here) Sources:
## How strong is the evidence for 5-Amino-1MQ?
**Preclinical** (2 of 5). Animal studies only + anecdotal; no human trials
_Mostly cell and animal studies. Human effects unknown._
## Questions about 5-Amino-1MQ
### What is 5-Amino-1MQ?
Small-molecule (not a peptide) membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme in fat tissue that consumes NAD+ precursors. Not a peptide: a small-molecule inhibitor of the enzyme NNMT, often sold and discussed alongside peptides.
### Is 5-Amino-1MQ FDA-approved?
A March 2026 report on FDA warning letters says FDA inspectors found that compounder GenoGenix made 5-Amino-1MQ, which is ineligible for the section 503B compounding exemptions.
### What is 5-Amino-1MQ researched for?
The sources cited on this page most often discuss three outcomes: Fat loss, mice; Aged muscle regeneration, mice; Metabolic health, mice. Each line above shows what the source reports and how strong that evidence is.
### What side effects of 5-Amino-1MQ are reported?
Reported in the cited sources: No observable adverse effects in mouse study; human efficacy, dose and long-term safety unknown; Mild stomach upset, headaches, fatigue and occasional nausea, mostly when starting; Diarrhea reported with oral tablets by one user also taking retatrutide, so the cause is unclear. The list is not complete, and few listed risks does not mean a compound is safe.
### How strong is the evidence for 5-Amino-1MQ?
Evidence label: Preclinical. Animal studies only + anecdotal; no human trials.
### What else is 5-Amino-1MQ called?
Names used for it include 5-amino-1-methylquinolinium iodide, 5amino, 5A1MQ, 5AM1.
### Does humanpeptides.fyi recommend 5-Amino-1MQ?
No. humanpeptides.fyi makes no claims and no recommendations of its own. It summarizes and links to what others have published and posted. Nothing here is medical advice; talk to a licensed clinician.
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