--- title: "DSIP: what sources report" url: https://humanpeptides.fyi/peptides/dsip site: humanpeptides.fyi last_reviewed: 2026-10-11 --- # DSIP > humanpeptides.fyi makes no claims of its own. Every statement below reports what a cited source says, with its link. Not medical advice. DSIP: Nonapeptide first isolated from rabbit brain during induced slow-wave sleep. The sources cited here most often discuss it for: Sleep, small mixed trials; Withdrawal relief, old uncontrolled study; Stress-axis calming, early data. Evidence label: Early human. ## At a glance - **Type:** Peptide - **Family:** Mind & Mood - **Evidence label:** Early human (3 of 5) - **Regulatory status:** On July 24, 2026, FDA's Pharmacy Compounding Advisory Committee voted 6 to 7 against adding emideltide (DSIP) to the 503A bulks list after FDA reviewed it for opioid withdrawal, chronic insomnia and narcolepsy. - **Goals discussed:** Sleep, Calm & Mood - **Also called:** Emideltide, Deltaran, WAGGDASGE, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, Delta sleep-inducing peptide - **Last reviewed:** 2026-10-11 ## What is DSIP? - Nonapeptide first isolated from rabbit brain during induced slow-wave sleep; mechanism unresolved (no receptor or gene identified); not FDA-approved, sold as research peptide. Sources: , **Regulatory status:** On July 24, 2026, FDA's Pharmacy Compounding Advisory Committee voted 6 to 7 against adding emideltide (DSIP) to the 503A bulks list after FDA reviewed it for opioid withdrawal, chronic insomnia and narcolepsy. Source: ## What is DSIP researched for? ### 1. Sleep, small mixed trials - Sleep: small double-blind insomnia studies were inconsistent - one 1987 study of 14 severe insomniacs reported improved sleep and daytime performance; another 1987 study found no significant effect vs placebo; a 1992 study found only weak, clinically insignificant changes (small human RCTs, mixed) Sources: , , - Goals: [Sleep](https://humanpeptides.fyi/objectives/sleep) ### 2. Withdrawal relief, old uncontrolled study - Withdrawal symptoms: in 107 alcohol/opiate withdrawal patients, rapid symptom improvement reported in 97% of opiate and 87% of alcohol cases (old uncontrolled human study) Sources: , - Goals: [Calm & Mood](https://humanpeptides.fyi/objectives/mood) ### 3. Stress-axis calming, early data - Stress-axis modulation: reduced CRF-induced corticosterone in rats and lowered basal ACTH in normal men, though no effect on CRH- or meal-induced ACTH/cortisol in humans (animal + small human studies) Sources: , , - Goals: [Calm & Mood](https://humanpeptides.fyi/objectives/mood) ## What do researchers and users say about DSIP? > "Thus the hypothesis regarding DSIP as a sleep factor is extremely poorly documented and still weak." > > Kovalzon VM, Strekalova TV, Delta sleep-inducing peptide (DSIP): a still unresolved riddle (Journal of Neurochemistry, 2006). Context: Mini-review abstract; no DSIP gene, precursor protein or receptor had been identified. > "DSIP became famous because of what it promised. It never earned the same reputation in human clinical research." > > Chris Barry, BetterSleep, DSIP for Sleep: Does the "Delta Sleep" Peptide Work?. Context: Closing of a 2026 evidence review of the small 1980s and 1990s insomnia trials. > "I started hitting what feels like genuinely deep, restorative sleep the kind where you wake up and feel like your nervous system actually recovered." > > Anonymous user, r/BodyHackGuide, DSIP works, but requires patience. Context: One user's self-report after about three weeks; the same user first had more trouble falling asleep. Anecdotal. ## What side effects of DSIP are reported? - User-reported headaches, nausea/dizziness, grogginess, vivid dreams; no established dosing, bioavailability or long-term safety data (anecdotal) Sources: , - FDA flagged a risk of immune reactions from aggregation and peptide impurities in compounded emideltide and found no safety information for the proposed route. (FDA safety review) Sources: - Used alongside isoflurane anesthesia in humans, DSIP raised heart rate and made anesthesia lighter rather than deeper. (human study) Sources: - Some users report more trouble falling asleep during the first weeks. (anecdotal) Sources: - Independent testing of research peptides has found products whose contents differ from their labels. (journalist review) Sources: ## What do peptide guides say about DSIP? - **PepEdHub:** PepEdHub presents DSIP as a deep-sleep promoter it says acts through GABA, serotonin and cortisol pathways without next-day drowsiness, while acknowledging long-term safety data are limited. - **Seek Peptides:** Seek Peptides lists DSIP for sleep quality, insomnia and stress, but notes it is used less often than other peptides and that reported results are mixed. - **FDA:** FDA reviewed DSIP, under the name emideltide, for opioid withdrawal, chronic insomnia and narcolepsy ahead of its July 2026 compounding advisory committee meeting. - **BetterSleep:** A 2026 BetterSleep review notes the human DSIP studies were small, mostly from the 1980s and early 1990s, and gave the peptide intravenously in sleep labs rather than at home. ## What does the research say, system by system? ### Hormones & physiology - Lowered basal ACTH in normal men; no effect on stimulated ACTH/cortisol (human); reduced CRF-induced corticosterone in rats (animal) Sources: , ### Brain, mood & sleep - Mixed small trials for insomnia Sources: - Users report deeper sleep, fewer wake-ups, vivid/lucid dreams after days-weeks; others no effect or worse sleep; not a sedative (anecdotal/Reddit) Sources: , , ### Also notable - Described in literature as 'a still unresolved riddle' given decades without clear mechanism Sources: ## How strong is the evidence for DSIP? **Early human** (3 of 5). Few small, old human trials with inconsistent results; mostly anecdotal today _Small, short, old, unblinded or single-group human studies._ ## Questions about DSIP ### What is DSIP? Nonapeptide first isolated from rabbit brain during induced slow-wave sleep. ### Is DSIP FDA-approved? On July 24, 2026, FDA's Pharmacy Compounding Advisory Committee voted 6 to 7 against adding emideltide (DSIP) to the 503A bulks list after FDA reviewed it for opioid withdrawal, chronic insomnia and narcolepsy. ### What is DSIP researched for? The sources cited on this page most often discuss three outcomes: Sleep, small mixed trials; Withdrawal relief, old uncontrolled study; Stress-axis calming, early data. Each line above shows what the source reports and how strong that evidence is. ### What side effects of DSIP are reported? Reported in the cited sources: User-reported headaches, nausea/dizziness, grogginess, vivid dreams; no established dosing, bioavailability or long-term safety data; FDA flagged a risk of immune reactions from aggregation and peptide impurities in compounded emideltide and found no safety information for the proposed route; Used alongside isoflurane anesthesia in humans, DSIP raised heart rate and made anesthesia lighter rather than deeper. The list is not complete, and few listed risks does not mean a compound is safe. ### How strong is the evidence for DSIP? Evidence label: Early human. Few small, old human trials with inconsistent results; mostly anecdotal today. ### What else is DSIP called? Names used for it include Emideltide, Deltaran, WAGGDASGE, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, Delta sleep-inducing peptide. ### Does humanpeptides.fyi recommend DSIP? No. humanpeptides.fyi makes no claims and no recommendations of its own. It summarizes and links to what others have published and posted. Nothing here is medical advice; talk to a licensed clinician. --- Family: [Mind & Mood](https://humanpeptides.fyi/peptides?cat=mind). HTML version: . Disclaimer: