Selank
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)
What is Selank?
Selank: Synthetic heptapeptide analogue of the immune peptide tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed in Russia as an intranasal anxiolytic/nootropic. The sources cited here most often discuss it for: Less anxiety, small open studies; Less fatigue, small studies; Immune modulation, small study. Evidence label: Early human.
- Type
- Peptide
- Family
- Mind & Mood
- Evidence label
- Early human (3 of 5)
- Regulatory status
- FDA lists selank acetate (TP-7) among compounding nominations withdrawn by their nominators after being placed in its safety-risk category, noting possible immunogenicity and that the agency lacks important information on its safety in humans.
- Goals discussed
- Calm & Mood, Energy & Endurance, Focus & Cognition, Immunity
- Also called
- TP-7, Selank acetate, Selanc, TKPRPGP, Thr-Lys-Pro-Arg-Pro-Gly-Pro, NA-Selank, N-Acetyl Selank Amidate, selank nasal spray, chill peptide
- Last reviewed
- 2026-10-11
- Synthetic heptapeptide analogue of the immune peptide tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed in Russia as an intranasal anxiolytic/nootropic; thought to allosterically modulate GABA-A signaling and enkephalin breakdown; registered drug in Russia, NOT FDA-approved.12
NA-Selank (N-acetyl selank amidate) is a chemically modified analog sold in the research market; it is not the drug registered in Russia and has its own, thinner evidence base.
Regulatory status FDA lists selank acetate (TP-7) among compounding nominations withdrawn by their nominators after being placed in its safety-risk category, noting possible immunogenicity and that the agency lacks important information on its safety in humans. 3
Names as used in gyms, forums and gray-market listings. Reported, not endorsed; stacks have not been studied as combinations.
The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.
Rat study measuring expression of 84 neurotransmission genes in the frontal cortex after Selank or GABA.
What is Selank researched for?
The three outcomes most discussed for Selank in the sources below, as those sources report them. humanpeptides.fyi makes no claims of its own: a listed benefit can be unproven or can have failed in trials, and the label on each line says which.
What do researchers and users say about Selank?
FDA lacks important information regarding any safety issues raised by selank acetate administered to humans.
FDA safety summary for selank acetate (TP-7), listed among compounding nominations that were later withdrawn.
Tried it a couple years back for similar reasons, it smoothed out the sharp edges of anxiety without making me foggy. The effect was subtle but noticeable, like background noise turning down a notch.
Forum reply about intranasal Selank for anxiety; several other replies in the same thread report no effect at all.
What side effects of Selank are reported?
- Nasal irritation, sleep changes, occasional nausea/elevated heart rate, brief dullinganecdotal Reddit109
- No long-term Western safety data5
- FDA flags a possible immunogenicity risk from aggregation and peptide-related impurities in compounded selank acetate, and says it lacks human safety information.FDA assessment3
- Drowsiness reported by some intranasal users.anecdotal11
What do peptide guides say about Selank?
- Dr. Axe Dr. Axe's library rates Selank research-only and not FDA-approved, and says its cited human study looked at anxiety symptoms only, establishing neither cognitive enhancement nor a mechanism in people. 12
- PepEdHub PepEdHub describes Selank as a tuftsin-derived peptide with an added Pro-Gly-Pro tail for stability, says Russia approved it as a prescription anxiolytic, and reports no dependence, tolerance or withdrawal effects. 13
- Seek Peptides Seek Peptides lists Selank for anxiety, focus and mood without sedation, while describing its effects as subtle. 14
- NCBI PMC In rats, Selank shifted expression of 45 neurotransmission genes within an hour, a pattern that tracked GABA's own effects and suggests GABA-system modulation; this is animal data, not a human trial. 2
What does the research say, system by system?
Hormones & physiology1
Brain, mood & sleep2
Also notable1
- Marketed as non-sedating, non-addictive alternative to benzodiazepines, though no Western placebo-controlled trials exist1
How strong is the evidence for Selank?
Small Russian human studies (not placebo-controlled) + animal data + anecdotes; approved in Russia only
Small, short, old, unblinded or single-group human studies. How tiers work
Questions about Selank
What is Selank?
Synthetic heptapeptide analogue of the immune peptide tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed in Russia as an intranasal anxiolytic/nootropic. NA-Selank (N-acetyl selank amidate) is a chemically modified analog sold in the research market; it is not the drug registered in Russia and has its own, thinner evidence base.
Is Selank FDA-approved?
FDA lists selank acetate (TP-7) among compounding nominations withdrawn by their nominators after being placed in its safety-risk category, noting possible immunogenicity and that the agency lacks important information on its safety in humans.
What is Selank researched for?
The sources cited on this page most often discuss three outcomes: Less anxiety, small open studies; Less fatigue, small studies; Immune modulation, small study. Each line above shows what the source reports and how strong that evidence is.
What side effects of Selank are reported?
Reported in the cited sources: Nasal irritation, sleep changes, occasional nausea/elevated heart rate, brief dulling; No long-term Western safety data; FDA flags a possible immunogenicity risk from aggregation and peptide-related impurities in compounded selank acetate, and says it lacks human safety information. The list is not complete, and few listed risks does not mean a compound is safe.
How strong is the evidence for Selank?
Evidence label: Early human. Small Russian human studies (not placebo-controlled) + animal data + anecdotes; approved in Russia only.
What else is Selank called?
Names used for it include TP-7, Selank acetate, Selanc, TKPRPGP, Thr-Lys-Pro-Arg-Pro-Gly-Pro, NA-Selank, N-Acetyl Selank Amidate, selank nasal spray, chill peptide.
Does humanpeptides.fyi recommend Selank?
No. humanpeptides.fyi makes no claims and no recommendations of its own. It summarizes and links to what others have published and posted. Nothing here is medical advice; talk to a licensed clinician.